Morphological reorganization of periodontic tissues under experimental opioid influence for twelve weeks

Peculiarities of pathomorphological changes periodontal components rats under the long-term opioid influence during twelve weeks in experiment have been studied.Objective – to determine features structural tissues complex conditions experimental action opioids for weeks.Methods. Adult male were administered analgesic nalbuphine 12 weeks, gradually increasing doses every 2 weeks. The initial dose was 0.212 mg / kg, 11-12 - 0.3 kg. Components dental organ upper and lower jaws used as material histological examination. Sampling performed at end week experiment.Results. On preparations epithelium gums thinning, ulcers, desquamation, well presence areas necrosis inflammatory infiltrates determined. Microscopic examinations free part gingival sulcus revealed foci necrosis, accumulation purulent bodies, damage attachment defragmentation circular fibers, which led formation pockets. Destruction collagen fibrinoid edema noted own plate. In constituent periodontium, destruction fibers with detachment from connective tissue membrane cell, signs mucoid periodontium observed thrombosis stasis due coordination blood cells, excessive proliferation microvessels, diapedetic hemorrhage, progression hypoxia.Conclusions. alternative changes, deepening dystrophy, soft severe hemomicrocirculation. Diffuse inflammatory-dystrophic process insufficient activity reparative processes, indicated irreversible nature developed against background chronic exposure.